Here, we confirmed that the protein expression of Caspase1, NLRP3, and GSDMD-N and the LDH, TNF-α, IL-1β, and IL-6 levels were upregulated in TBHP-treated NPCs, implying that pyroptosis occurs in IDD, suggesting that degeneration of the intervertebral disc is accompanied by inflammatory death or pyroptosis of NPCs. Here, IL1B is linked to intervertebral disk degenerative disorder.