SQYSF has a significant therapeutic effect on renal fibrosis in mice, which is manifested in the significant inhibition to the expression of inflammatory factors (TNF-α, IL-1β and IL-6), in addition to significantly changing mice’s composition intestinal flora; moreover, SQYSF is capable of greatly improving the abundance of Succinivibrionaceae and Aeromonadales in the mouse intestine. This evidence concerns the gene IL6 and renal fibrosis.