AKT1 and neoplasm: The results revealed that tumor volume and weight were significantly reduced under treatment with sh-SETDB1 + oe-NC + CDDP, the effect of which was abolished by AKT overexpression; treatment of oe-SETDB1 + oe-AKT + CDDP or sh-SETDB1 + oe-SETDB1 + CDDP could rescue the effect of sh-SETDB1 + oe-NC + CDDP on the tumor volume and weight.