Here, we further demonstrated that miR-378a-3p mimic transfection into HCC cells in the co-culture model resulted in the downregulation of IL-10 and TGF-β and the upregulation of IFN-γ, IL-2, and TNF-α, thus reflecting the activity of effector T cells [48,49]. The gene discussed is TNF; the disease is hepatocellular carcinoma.