WB analysis showed that miR-378a-3p overexpression effectively decreased the protein levels of STAT3 and p-STAT3 in Li-7 and HuH-7 cells, indicating that miR-378a-3p probably blocks the formation of HCC tumors by controlling the STAT3 signaling pathway (Figure 6(b)). This evidence concerns the gene STAT3 and hepatocellular carcinoma.