qRT-PCR showed that interference with the expression of LINC00115 activated the expression of miR-489-3p in RB cells (P < 0.01), and the expression of miR-489-3p activated upon LINC00115 silencing in RB cells was neutralized by miR-489-3p inhibitor (P < 0.01, Figure 4(a)), suggesting that si-LINC00115 restored the expression of miR-489-3p in RB. Here, LINC00115 is linked to retinoblastoma.