LGR5 and cancer: The expression of CD44, PROM1 (CD133), LGR5, SOX2, TFRC (CD71), CXCR4, and JAG1, markers of cancer stem cells (CSCs),26, 27, 28, 29 was also significantly upregulated in G3 compared with that in the other subclusters of malignant epithelial cells (Figures 2F and S4A).