Thus, we calculated the proliferation and migration scores for subclusters G0–G3 based on the expression of genes related to tumour cell proliferation (MKI67, IGF1, ITGB2, PDGFC, JAG1, and PHGDH)31, 32 or migration (VIM, SNAI1, MMP9, AREG, ARID5B, and FAT1).21, 22, 33, 34. This evidence concerns the gene JAG1 and neoplasm.