The results showed that patients with high scores of this 20‐gene signature in exhausted CD8+ T cells derived from the lymph node metastasis samples, had a significantly shorter survival than those with lower scores (p < .01) (Figure 7D), indicating great potential of this 20‐gene signature to prognosticate patient survival. The gene discussed is CD8A; the disease is metastatic malignant neoplasm in the lymph nodes.