CD8A and metastatic malignant neoplasm in the lymph nodes: As shown in Figures 7B and S17B, in exhausted CD8+ T cells, expression of the top 20 upregulated DEGs of the lymph node‐derived subset was higher in LN than in other metastases, which were also higher expressed in PT3 (the primary tumour sample from the patient who had lymph node metastasis) compared with other primary tumour, suggesting the 20‐gene signature reflects the patterns of metastatic spread from the primary site to lymph node.