In the top 20 upregulated DEGs of lymph node‐derived exhausted CD8+ T cells (Figure 7B), CXCL13, CXCR4, CH25H, HSPD1, HSP90AA1, and ATF3 have been confirmed to promote lymph node metastasis in several cancer types.115, 116, 117, 118, 119, 120. This evidence concerns the gene CD8A and cancer.