Figure 4E shows a dominant crosstalk between endothelial cells and G0 cells through angiogenesis signalling, particularly for E0 and E3, which receive potential angiogenic stimulatory signals from angiogenic G0 cells through VEGFA and its receptor FLT1 (also known as VEGFR1), key promoters of angiogenesis in cancer, including GC. The gene discussed is VEGFA; the disease is cancer.