In this study, not only the cancer subclusters (G0, G1, and G3) but the E1, MAIT in M, T cell‐like B cells, pDCs, Ma0–Ma3, Mo0–Mo3, and N0–N5 were predicted to express HLA‐E binding KLRC1/KLRC2 in cytotoxic/exhausted CD8+ T cells and/or NK cells, which might induce immunosuppression to promote GC metastasis. This evidence concerns the gene HLA-E and cancer.