Notably, the gene expression network of the T‐cell exhaustion signalling pathway showed that FOXO1, FOXP1, and JUN were activated (Table S2), and these genes were related to the inhibition of CD8+ T‐cell effector and memory functions and induction of T‐cell unresponsiveness in cancer,66 supporting the notion that E1 cells suppress the immune response. Here, CD8A is linked to cancer.