It has been reported that nucleotide‐binding and oligomerization domain‐like receptor (NLR) family pyrin domain containing 3(NLRP3), caspase‐1, and gasdermin D (GSDMD) are activated in D‐galactosamine/lipopolysaccharide (D‐gal/LPS)‐induced acute liver failure [9]. The gene discussed is NLRP3; the disease is acute liver failure.