To screen the potential and novel biomarkers of inflammation or colitis‐to‐carcinoma transition in humans, we identified three homeotic circRNAs of mmu_circ_0001109 (hsa_circ_0061166, hsa_circ_0061168 and hsa_circ_0092333) from the same host gene RTEL1. Here, RTEL1 is linked to colitis.