To study whether EPB41L4A‐AS1 contributes to T2DM, through gene expression analysis of the GSE2334330 and GSE679831 datasets obtained from the Gene Expression Omnibus (GEO) database, EPB41L4A‐AS1 expression was found to be abnormally increased in the liver of patients with T2DM and up‐regulated in the muscle cells of patients with insulin resistance (Figure 1A and B). This evidence concerns the gene EPB41L4A and Insulin resistance.