In summary, we studied the function of EPB41L4A‐AS1 in T2DM cell models, and this is the first study to show that the EPB41L4A‐AS1/GCN5 complex repressed glucose uptake by targeting GLUT4/2 and TXNIP and by regulating histone and non‐histone acetylation or crotonylation (Figure 8). Here, SLC2A4 is linked to type 2 diabetes mellitus.