Compared with other candidate genes such as PPIF, SRGN and AGO2, PTGS2 (COX‐2), one of the famous genes selected as above with most essential in the M2 polarization and pro‐tumour function of TAMs cells in previous reports, was chosen as a typical example for analyzing the mechanism of CTCF acting as a transcription factor in tumorigenesis (Figure 3D and Figure S12B).36, 37, 38, 39, 40, 41. The gene discussed is PPIF; the disease is neoplasm.