We further assessed the impact of CTCF expression in macrophages on supporting tumour metastasis in a PDAC mouse model of liver metastasis, in which PANC‐1 cells mixed with CTCF knockdown or control macrophages (THP‐1 shNC/sh1 CTCF cells) were injected into the spleens of BALB/c nude mice. This evidence concerns the gene CTCF and neoplasm.