MRC1 and neoplasm: To characterise the accessible chromatin landscape in TAMs, we used MACS to isolate high‐purity CD206+ cells which were indeed macrophages from tumour tissues and high‐purity CD14+ cells from peripheral blood from PDAC patients and compared the genome‐wide maps of ATAC‐seq between CD206+ TAMs and CD14+ monocytes (Figure 1A and Figure S1A–F).