To address the role of OMD during atheroprogression and the development of intimal calcification, we utilised a model where ApoE−/− mice received a western‐type diet (WTD) supplemented with warfarin and vitamin K133 (Figure 4A), gradually developing severe calcification in the aortic arch and the innominate artery over the course of 19 weeks. The gene discussed is APOE; the disease is occult macular dystrophy.