OMD and congenital bilateral aplasia of vas deferens from CFTR mutation: In summary, our translational approach integrating data from three patient cohorts with late‐stage CKD, CAVD and atherosclerosis, murine models of intimal and medial calcification and in vitro mechanistic studies, identified OMD as a novel factor broadly upregulated in both plasma and local tissue in association with cardiovascular calcification.