Correlation of OMD with osteochondrogenic and glycoprotein markers (Figure 2K,L) revealed that the transcript was associated negatively with RUNX2, an osteogenic transcription factor essential for bone formation, and SOX9, a master regulator of cartilage differentiation, while positively with BMP2, required for osteoblast differentiation. The gene discussed is RUNX2; the disease is occult macular dystrophy.