Graphic working model illustrates that SFRS8 reduces CACYBP isoform1 (NM_014412.3) and increases CACYBP isoform2 (NM_001007214.1) by mediating the alternative splicing of CACYBP, thereby altering the ubiquitination degradation of β‐catenin and exosome‐based cellular communication to promote MM malignancy and bone lesion. The gene discussed is CACYBP; the disease is Miyoshi myopathy.