Finally, our own immunohistochemistry (IHC) analysis of 14 normal lung tissues compared to 140 LUAD tumor tissues also demonstrated higher levels of NRF2, SLC7A11 and Rep2 in LUAD lung tissue compared to normal controls, in addition to a strong correlation between Rep2 and SLC7A11 expression and NRF2 protein levels (Fig. 2H‐I). This evidence concerns the gene CHML and neoplasm.