Indeed, elevated SphK1 protein expression was detected in a variety of cell models (such as 22RV, ARCaP‐IIB5 and ‐IIG5, and PC3) expressing NE phenotype compared with that in AR‐positive ADPC cell models (such as LNCaP, C4‐2, C4‐2B and VCAP) (Supporting information Figure S1E), however, the ubiquitous expression of SphK2 was associated with every PCa cell lines. The gene discussed is SPHK1; the disease is posterior cortical atrophy.