SPHK1 and posterior cortical atrophy: Hence, we further investigated the role of SphK1 in developing Enzalutamide resistance of PCa by co‐culturing both vector control (VC) LNCaP labeled with mCherry and CA‐SphK1 LNCaP labeled with GFP at 100:1 ratio in the presence of Enzalutamide (Figure 1F, right panel).