TSPAN6 and neoplasm: Importantly, when we implanted control (no Dox) and Dox-induced MIA PaCa2 and PANC1 cells orthotopically into the pancreas of immunodeficient nu/nu mice, TSPAN6 overexpression markedly reduced tumor growth within the primary pancreatic injection site and significantly decreased metastatic spread to distant sites (Fig. 3d–f and Supplementary Fig. 4a–e).