MKI67 and adenoma: Proliferation, as detected by Ki67 staining, was significantly enhanced in hyperplastic regions, as well as in early (4 weeks after Ad-Cre inhalation) adenomas and adenocarcinomas from Tspan6−/yKrasG12D mice compared to their Tspan6+/yKrasG12D littermates (Supplementary Fig. 5d, e).