Moreover, induction of TSPAN6 in human pancreatic cancer cells inhibits EGFR-induced expression of the EMT markers Vimentin and N-Cadherin, as well as the critical EMT transcription factor Slug, thereby linking TSPAN6 to the inhibition of EGFR-mediated EMT in human tumor cells. This evidence concerns the gene TSPAN6 and familial pancreatic carcinoma.