We found that low expression of TSPAN6 correlated with pancreatic adenocarcinomas with an EMT signature (Panc-exoc and Panc-Qm) relative to those with an epithelial signature (Panc-epith) in two pancreatic cancer cohorts [37, 38] (Fig. 7c). Here, TSPAN6 is linked to familial pancreatic carcinoma.