Recently, radiation was shown to induce an immune reaction in the tumour tissue and surrounding immune cells via the micronucleus-forming STING-type I interferon (IFN) pathway in vitro and in vivo, which is considered as a master regulator of the cancer-immune reaction including the immune reaction in the tumour microenvironment (TME) triggered by irradiation [12]. The gene discussed is IFNA1; the disease is neoplasm.