Another mitophagy activator, NMN supplementation could not only activate PINK1-parkin-mediated mitophagy in the prion disease cell model but also restore mitochondrial morphology and function, thereby alleviating neuronal apoptosis induced by PrP106-126, the therapeutic effect of NMN has also been reported in other diseases, such as premature aging-related ataxia telangiectasia and hypertension-related stroke [50, 51]. Here, PRKN is linked to prion disease.