In contrast, when two cancer cell lines that did not upregulate F9, SKMEL28 (Fig. 5D) and MDA-MB-468 (Fig. S6C) were treated with the conditioned media of Palbo-treated MCF7 or iRAS cells, no differences could be observed in the levels of F9 mRNA (Fig. S6D) in spite of F9 mRNA levels being upregulated upon 4OHT treatment in iRAS cells (Fig. S6E). The gene discussed is F9; the disease is cancer.