In prior ICI-treated and ICI-naive subgroups, these grade greater than or equal to 3 events occurred in 15% and 18% (hypertension), 14% and 9% (increased ALT), 12% and 5% (increased AST), and 6% and 4% (thrombocytopenia) of patients, respectively. The gene discussed is GPT; the disease is hypertensive disorder.