EGFR and cancer: As previously reported [26], and in accordance with what was observed in the METABRIC and TCGA cancer datasets (Additional file 2: Supplementary Fig. 3), EGFR expression is downregulated in tumors as compared with the normal breasts (2.4-fold reduction, p < 0.0001 for positivity, 2.6-fold reduction, p < 0.0001 for H-score; Fig. 3A).