Such mediator comprises various cytokines and growth factors that induce cell proliferation and migration, proangiogenic growth factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and transforming growth factor-β (TGF-β), NF-kB-mediated factors that protect against apoptosis, and proangiogenic growth factors [58, 59] that favor cancer cell migration and metastasis. This evidence concerns the gene VEGFA and cancer.