To block the CCL2-CCR2 axis, researchers designed siRNA-CCR2-encapsulated cationic nanoparticles (CNP-siCCR2) to suppress the expression of CCR2 in monocytes by blocking the CCL2-CCR2 axis and reshaping the TME to inhibit tumor growth and metastasis [127]. This evidence concerns the gene CCL2 and neoplasm.