Metastatic cells use the CCL2-CCR2 pathway to attract monocytes and differentiate them into metastasis-associated macrophages (MAMs) that support tumor cell survival and metastasis by suppressing T cells and, interestingly, ablating the recruitment of MAMs, reducing metastasis and prolonging animal survival, implying that they could be used as therapeutic targets [69, 70]. The gene discussed is CCL2; the disease is neoplasm.