Zhang et al. engineered CAR targeting HER2 for macrophages, which consists of one variable region that binds to HER2 to increase the expression of MMPs for degradation of ECM and another intracellular region made up of CD147, which promotes the infiltration of T cells into the TME and subsequently inhibits the tumor growth in a 4 T1 murine breast tumor model [119]. This evidence concerns the gene ERBB2 and breast neoplasm.