In another recent study, researchers developed anti-CCR7 CAR-M cells that direct macrophages toward CCR7-positive cells and remove CCR7-positive cells by screening the intracellular activation domains that trigger tumor cell cytotoxicity, which inhibit tumor growth, prevent metastasis, and induce systemic antitumor immunity, effects that collectively prolong survival [122]. Here, CCR7 is linked to neoplasm.