In recent studies, researchers also focused on CCL19 or macrophage inflammatory protein 3 beta (MIP-3β) to enhance the interaction among immune responses using the targeted gene delivery system with 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), methoxy poly (ethylene glycol)-poly (lactide) (MPEG-PLA), and folic acid-modified poly (ethylene glycol)-poly(ε-caprolactone) (FA-PEG-PCL) (FDMCA) to polarize macrophages toward M1, inhibiting tumor growth and metastasis in mouse models [165]. Here, CCL19 is linked to neoplasm.