Chen et al. developed a postsurgical immunotherapeutic fibrin gel (aCD47@CaCO3) using calcium carbonate nanoparticles preloaded with CD47 antibody that gradually dissolve and release aCD47 in tumors in a controlled manner, which encourages the activation of M1-type macrophages and induces the phagocytosis of cancer cells by macrophages, boosts the antitumor immune response and inhibits local tumor recurrence and metastasis postsurgery [152]. The gene discussed is CD47; the disease is cancer.