SIRT1 and colorectal carcinoma: According to the data, xenograft tissues of mice injected with β-catenin overexpression CRC cells presented with elevated mRNA and protein expression levels of β-catenin and nearly unchanged FOXQ1 and SIRT1 as compared with those of mice injected with NC CRC cells; compared with β-catenin overexpression alone, its combination with FOXQ1 knockdown led to decreased levels of FOXQ1, SIRT1 and β-catenin (Fig. 9A-B).