Taken together, the data acquired in the present study led to a conclusion that FOXQ1 may induce SIRT1 expression, trigger the nuclear translocation and activity of β-catenin, enhance the stemness of CRC cells and benefit CRC-related intestinal pathological bacteria, thereby inducing the resistance of CRC cells to radiation (Fig. 10). The gene discussed is SIRT1; the disease is colorectal carcinoma.