The mRNA expression of tumor stem cell markers (CD133, SOX2 and OCT4) in the CRC xenograft tissues of mice was then found to be up-regulated in the presence of β-catenin overexpression alone, and the up-regulation was reversed when β-catenin overexpression was combined with FOXQ1 knockdown (Fig. 9D). The gene discussed is POU5F1; the disease is colorectal carcinoma.