Additional limitations of HRP2 RDT kits include the persistence of HRP2 antigen in the blood for up to four weeks after the clearance of an active infection, which results in high false-positive rates [22] and the increasing reports of false-negative results due to the presence of parasites not producing HRP2 as a result of pfhrp2 gene deletions [23]. This evidence concerns the gene HDGFL2 and infection.