On the other hand, serum albumin retains a well-known antioxidant role, other than exerting a significant anticoagulant action: in detail, two recent studies evidenced that hypoalbuminemia is significantly associated with worst COVID-19 prognosis and that albumin supplementation, in preliminary studies, could even play a role in reducing the incidence of thrombotic complications and then, the overall mortality [22, 24, 38]. The gene discussed is ALB; the disease is COVID-19.