PARK7 and Parkinson disease: In fact, DJ-1 mutations have been related to tau hyperphosphorylation (Wang et al. 2013) and it has been widely described that DJ-1 colocalises with tau inclusions in brains from PD patients indicating that DJ-1 can act as a chaperone modulating the aggregation and toxicity of tau as has been demonstrated for other proteins that form inclusions, such as α-synuclein, mutant huntingtin, and microtubule-associated protein 1B (MAP1B) (Zondler et al. 2014; Wang et al. 2011; Repici and Giorgini 2019).