PARK7 and early-onset autosomal dominant Alzheimer disease: The observed increase in AGEs in neurons lacking DJ-1 could also contribute to cell cycle activation since it has been shown that AGEs produced as a consequence of oxidative stress act as mitogenic compounds inducing expression of cyclin D and DNA replication in a mouse model of Alzheimer disease deficient for apolipoprotein E (Kuhla et al. 2015).