PTEN and Parkinson disease: The enrichment analysis, based on GO terms (significant differences in the frequency of the proteins identified relative to their frequency in the whole genome), showed that the most remarkable decreases were detected in proteins involved in proteolysis; induction of apoptosis; signalling related to cell proliferation and survival ,such as p21-activated kinase (PAK), phosphatase and tensin homolog (PTEN) and nuclear factor-κB (NF-κB); mitochondrial dysfunction; and Parkinson’s disease (Fig. 1B, Supplementary Fig. 1A).