In a subanalysis of the phase 3 CheckMate 227 study in Asian patients with tumor PD-L1 expression ≥ 1% or < 1%, first-line treatment with nivolumab plus ipilimumab combination therapy demonstrated durable long-term survival and clinical benefits versus chemotherapy (median OS not reached versus 22.9 months; 2-year OS rate, 53% versus 45%, respectively), consistent with OS improvements observed in the all randomized population [29]. Here, CD274 is linked to neoplasm.