Urinary albumin/creatinine ratio (ACR) within the upper tertile (high ACR) of the normoalbuminuric range during the early years following type 1 diabetes diagnosis is associated with future risk of kidney disease [2] and cardiovascular risk [3], impaired cardiac autonomic function [4] and early alterations in the retinal microvasculature [5], when compared with a lower ACR despite shorter diabetes duration. This evidence concerns the gene ALB and type 1 diabetes mellitus.