SPRY2 and breast carcinoma: Other negatively correlated validated targets for miR‐21‐5p included the mRNAs of LIFR, a metastasis suppressor in breast cancer,43 and SPRY2, a negative regulator of RAS and MAPK signalling,44 with Pearson correlations of −0.46 and −0.42, respectively (P = 4.9e − 60 and 5.4e − 48).