Our previous study and studies by others showed that overexpression of YAP regulated the glucose transporter and promoted glycolysis in metastatic colorectal and brain tumor cells.[15] A recent study reported that activation of YAP enhanced FAO activity in lymph node metastatic tumor cells;[16] however, the contribution of YAP to this adaptation toward FAO is still unclear. The gene discussed is YAP1; the disease is metastatic neoplasm.