To identify oncogenic signaling events associated with metabolic reprogramming in HFD tumor cells, we revisited upregulated genes from RNA sequencing, and gene ontology analysis revealed that enriched pathways included phosphoinositide 3‐kinases (PI3K)‐protein kinase B (AKT), FoxO, hypoxia‐inducible factor‐1, and Janus kinase‐signal transduction and activator of transcription in HFD tumor cells (Figure3A). Here, AKT1 is linked to neoplasm.