Thus, combining the in vivo and in vitro experimental results and the conclusions of the cross‐sectional study, our study strongly clarified that by suppressing the NF‐κB signalling pathway, Nur77 downregulates the expression of hsCRP, IL‐6 and TNF‐α, thereby effectively preventing osteoclast differentiation and osteoporosis. This evidence concerns the gene IL6 and osteoporosis.