We found that CatE deficiency had no effect on the expression of tissue‐type plasminogen activator (tPA), insulin‐degrading enzyme (IDE) Aβ‐degrading enzymes including neprilysin (NEP) and angiotensin‐converting enzyme (ACE) in the cortex and hippocampus of 6‐month‐old AD and AD/CatE−/− mice (Figure S2a,b). This evidence concerns the gene IDE and Alzheimer disease.