CatE has been reported to be involved in the proteolytic activation of TRAIL in microglia, and blockade of sTRAIL by neutralizing antibodies has been shown to result in functional improvement and a restrained immune/inflammatory response in the brains of 3xTg‐AD mice in vivo(Cantarella et al., 2015; Ni et al., 2015). This evidence concerns the gene CTSE and Alzheimer disease.