Notably, the expression of TRAIL was significantly increased in microglia purified from the brains of 6‐month‐old AD mice, and death receptor 5 (DR5), the major receptor of sTRAIL, was upregulated in both microglia and neurons from the brains of 6‐month‐old AD mice. The gene discussed is TNFSF10; the disease is Alzheimer disease.