In rats with monocrotaline-induced PAH, A2AR agonists, LASSBio-1386 [70] and LASSBio-1359 [71, 72], improved structural and functional alterations in heart and pulmonary artery, whereas A2A−/− mice showed PAH, pulmonary vascular constriction, and pulmonary artery remodelling compared to WT littermates [73, 74]. The gene discussed is ADORA2A; the disease is pulmonary arterial hypertension.