Polymorphisms of genes controlling ANP and its receptor expression as ANP A2843G and A188G, ScaI polymorphism of ANP gene, and the natriuretic peptide clearance receptor (NPRC) gene polymorphism C (-55) A were studied in some disorders as essential hypertension and chronic heart failure [11, 12] but never been explored before in INS. This evidence concerns the gene NPPA and essential hypertension.