ANP level distribution according to degree of edema did not show significant difference between patients with 1-puffy eyes+ LL edema + ascites (ANP 132.6±61.3 ng/ml), 2-patients with edema As 1 + scrotal or vulval edema (ANP level 127.01±49.2 ng/ml), 3-patients with edema as 1 or 2 +pleural effusion (ANP 125.4±41.8 ng/ml). Here, NPPA is linked to Pleural effusion.