Also, senescent fibroblasts can promote growth and proliferation of tumor cells via secretion of SASP intermediates (e.g., fibroblast growth factors 10 and 19, IL-1β), epithelial-mesenchymal transition (IL6, MMP2-3), and immune evasion mechanisms (i.e., IL-6 drives accumulation of suppressive myeloid cells and their activity) [124]. The gene discussed is IL6; the disease is neoplasm.