Shortly after gene identification, it was demonstrated that overexpression of the FUS1/TUSC2 transgene in FUS1/TUSC2-deficient lung cancer cells suppressed proliferation, blocked G1/S or G2/M transition, and increased doubling time implying a tumor suppressor role for FUS1/TUSC2 [46, 47]. This evidence concerns the gene TUSC2 and lung carcinoma.