PRKN and adenocarcinoma: Two likely pathogenic variants were identified in patient ID 5: the missense variant c.758G > A (Arg253His) in the gene PARK2 (or PRKN2) and the frameshift insertion c.4259dupC (p.Pro1420fs) in the DNA repair gene SLX4. The patient was diagnosed at 38 years old with moderately differenced adenocarcinoma in the left colon (Supplementary Fig. 8).