The discriminative ability of this model was higher compared to a model containing repeated measurements of established biomarkers NT-proBNP, hs-TnT, eGFR and adjusted for baseline clinical predictors, and equal to a model containing a set of biomarkers previously shown to be involved in HF (NT-proBNP, hs-TnT, hs-CRP, GDF15, ST2, PAI-1, Gal3). The gene discussed is SERPINE1; the disease is hydrops fetalis.