In conclusion, 9 out of 92 serially measured circulating proteins, related to processes which are dysregulated in cardiovascular disease, provided the optimal multivariable model for occurrence of adverse clinical events in HF patients: NT-proBNP, ST2, vWF, FABP4, IGFBP1, PAI-1, TfR, CHIT1, and PON3. This evidence concerns the gene PON3 and hydrops fetalis.