However, here we show that the predictive value of repeated NT-proBNP measurements as reported previously12 may be further increased when NT-proBNP is measured together with 8 other proteins involved in biological mechanisms that have been implicated in HF, i.e. inflammation and cardiac remodeling (ST2, CHIT1), thrombosis and hemostasis (vWF, PAI-1), the endocrine system (FABP4, IGFBP1), iron homeostasis (TfR), oxidative stress (PON3). The gene discussed is PON3; the disease is hydrops fetalis.