In addition, the ratio of CD4+CD25+Foxp3+ cells was reduced to 56.5% in the tumor tissues of BALB/c mice inoculated with LN229 cells transfected with sh-lncRNA HOXA-AS2, while it was reduced to only 29.2% in tumor tissues of BALB/c mice inoculated with A172 cells transfected with sh-lncRNA HOXA-AS2 (Fig. 2H). The gene discussed is FOXP3; the disease is neoplasm.