IHC exhibited that lncRNA HOXA-AS2 silencing potently reduced KDM2A and JAG1 expression in tumor tissues of BALB/c mice, whereas JAG1 overexpression triggered the elevation in JAG1 expression in tumor tissues of BALB/c mice without impacting did KDM2A expression in the presence of lncRNA HOXA-AS2 silencing (Fig. 6B). Here, KDM2A is linked to neoplasm.