To further identify the function of lncRNA HOXA-AS2/miR-302a/KDM2A axis in glioma progression, we silenced lncRNA HOXA-AS2 using sh-lncRNA HOXA-AS2 and restored KDM2A expression using oe-KDM2A or repressed miR-302a using miR-302a inhibitor in LN229 and A172 cells. The gene discussed is KDM2A; the disease is glioma.