Interestingly, loss of YAP/TAZ also decreased PIEZO1 expression.118 In chondrocytes, PIEZO1 and PIEZO2 can act redundantly to mediate injury-induced osteoarthritis.119 In vivo studies have demonstrated the indispensability of PIEZO1 in the osteoblastic lineage, albeit with various phenotypes. This evidence concerns the gene PIEZO1 and osteoarthritis.