Indeed, in patients with luminal A BC there was no significant difference in terms of RFS (p = 0.63) or DSS (p = 0.68) between patients with PIK3CA-mut/neut or PIK3CA-wt/neut tumors, while in patients with luminal B BC a worse RFS and DSS was found for those with PIK3CA-mut/neut compared to PIK3CA-wt/neut, even though results were statistically significant only for DSS (p = 0.02; RFS p = 0.11) (Fig. 2b, c and Supplementary Fig. 3b, c). Here, PIK3CA is linked to breast cancer.