PIK3CA and cancer: As expected, both BC and pan-cancer PIK3CA-mut/neut cell lines showed significantly lower IC50 values compared to PIK3CA-wt/neut (p = 0.0059 and p = 1.1e−02, respectively) while pan-cancer, but not BC cells with PIK3CA-mut/gain showed significantly lower IC50 values compared to PIK3CA-mut/neut (p = 0.016 and p = 0.95, respectively) (Fig. 4a and supplementary Fig. 6a).