Cyclosporin A-mediated activation of ERK1/2, GSK3β and CK2 leads to phosphorylation of HSF1 at Ser303 and Ser307, which interferes with the formation of the HSF1-SSBP1 complex and reduces transcriptional activity of HSF1, resulting in the downregulation of HSP expression and inducing the death of cancer cells [128]. The gene discussed is HSF1; the disease is cancer.