Surprisingly, in previous studies, it has been proved that all of our defined switch genes, including Lamc2 [99], Klk1 [77], Nqo1 [110], Aox1 [105], Tspan1 [111], and Cxcl12 [112], are closely associated with the pancreatic cancer’s progression. This evidence concerns the gene NQO1 and familial pancreatic carcinoma.