KEAP1 and lung adenocarcinoma: Namani et al. have also found that not only Cxcl12 (as a switching gene) serves as an NRF2 binding site, but also both Slc9a9 and Man1a2 are highly correlated with the NRF2 pathway upregulation among the KEAP1-mutated Lung adenocarcinoma patients [104].