SIN3A and nervous system disorder: As is reported in some studies, MeCP2 in neurological diseases acts as both a transcriptional repressor by selectively binding to methylated CpG dinucleotides and recruiting co-repressors such as histone deacetylases and Sin3A, and a transcriptional activator by selectively binding to methylated CpG islands and recruiting activators such as CREB110 [23].