PKM and renal carcinoma: In addition, a previous study reported that silencing NOX4 through PKM2 sensitized cultured and ex vivo freshly isolated human-renal carcinoma cells to drug-induced cell death [19], and another study reported that EFHD2 promoted cisplatin resistance in non-small cell lung cancer by activating the NOX4-ROS-ABCC1 axis [18].