To determine the opposite results regarding NFIL3 expression at both the mRNA and protein levels, we first compared the degradation rate of NFIL3 between breast epithelial cell MCF10A and breast cancer cell Hs578T and between colon epithelial cell NCM460 and colonrectal cancer cell HCT15 respectively, and showed that there is no significant difference for degradation rate between cancer cell lines and their corresponding epithelial cells (Supplementary Fig. 1D-E). Here, NFIL3 is linked to breast carcinoma.