EGR3 and breast cancer: When considering the expression patterns of NFIL3 and EGR3 in different subtypes of breast cancer, we found that EGR3 mRNA was significantly downregulated in the HER2-positive subtype of breast cancer, whereas NFIL3 mRNA was specifically lower in the TNBC subtype than in the other subtypes of breast cancer (Fig. 1C).