Taken together, these features suggest that OPN3 is involved in a poor prognosis in some types of cancers, including BLCA, GBM, LGG, LIHC, LUAD, STAD and UVM, mainly by OPN3 gene variations, epigenetic modification (methylation and phosphorylation) patterns and/or affecting the infiltration of cancer-associated fibroblasts. This evidence concerns the gene OPN3 and glioblastoma.