OPN3 and cancer: Next, Cox regression analysis of prognostic factors for OS of BLCA, GBMLGG, LIHC and STAD patients was performed (HR = 13.03 [95% CI: 3.76-45.17], p < 0.001; HR = 3.15 [95% CI: 1.54-6.43], p = 0.002; HR = 5.26 [95% CI: 1.97-14.04], p = 0.001; HR = 5.05 [95% CI: 2.06-12.38], p < 0.001, respectively) (Fig. S1), which showed that high OPN3 expression was significantly related to worse overall survival in these cancer types.