OPN3 and cancer: In seven types of cancers, including BLCA, GBM, LGG, LIHC, LUAD, STAD and UVM, Kaplan–Meier survival analysis showed that a significant difference in patient overall survival was found between the low and high OPN3 expression groups according to the OPN3 expression median value (Fig. 2A), revealing that high OPN3 expression was associated with shorter overall survival.