Consistent with this observation, we also found that overexpression of HO-1 significantly increased the levels of IFN-β and antiviral genes (including OAS1 and ISG15), whereas silencing of HO-1 decreased the levels of IFN-β and antiviral genes after virus infection (Figs 6G andS7D). The gene discussed is IFNB1; the disease is viral infectious disease.