IFNG and Autoimmunity: Nevertheless, Hif1a haploinsufficiency in Foxp3CremiR-142fl/fl mice failed to ameliorate the lethal autoimmunity (S6C Fig), nor did Hif1a deletion restore the suppressive capacity (S6F and S6G Fig) of miR-142-deficient Treg cells and attenuate the peripheral Teff cell hyperactivation (S6H Fig), perhaps because of a failure to effectively rescue aberrant IFNγ production and signaling in Treg cells (S6D and S6E Fig).