Our demonstration of lack of restoration of insulin content in NDM mice treated with DAPA at day 42 of diabetes correlate with no improvements in insulin biosynthesis/secretion in 16 week old db/db mice treated with luseogliflozin [25], and with absence of preservation of β-cell function in 15–20 week old db/db mice treated with dapagliflozin [28]. Here, INS is linked to diabetes mellitus.