NFKB1 and alkaline phosphatase measurement: 2017). Among them, oxidative stress and inflammatory response are two important aspects in the induction and progression of AP. Oxidative stress is an essential pathogenic factor placed at the crossroad between apoptosis and inflammation. Oxidative stress may lead to the activation of the nuclear factor-κB (NF-κB) and PI3K/AKT signalling pathways, which are involved in the generation and release of inflammatory cytokines in AP (Xiang et al. 2017).