IL6 and pancreatitis: 2017; Tarasiuk and Fichna 2019). Chlorogenic acid reduced the histological severity of pancreatitis and the levels of pancreatic lipase and amylase. In addition, macrophage migration inhibitory factor (MIF) was critical in mediating inflammatory cytokines and it was associated with the severity of AP. Chlorogenic acid significantly downregulated the levels of inflammatory cytokines and chemokines, such as IL-6, MIP-2 and MIF, in mouse serum and pancreatic tissue. Chlorogenic acid exerted an anti-inflammatory effect on l-arginine-induced AP (Ohkawara et al. 2017).