MAPK8 and alkaline phosphatase measurement: 2017). Furthermore, berberine decreased the levels of serum amylase and lipase, the levels of proinflammatory mediators (such as TNF-a, IL-1β and IL-6), the levels of inducible nitric oxide synthase (iNOS) and myeloperoxidase (MPO) activity in AP mice. Finally, berberine inhibited AP through suppression of the activation of the JNK, NF-κB and p38 MAPK signalling pathways (Choi et al. 2016, 2017).