HMOX1 and alkaline phosphatase measurement: 2016). In the cerulein-induced AP mouse model, ISL dose-dependently alleviated the histopathological change in pancreatic tissue. Moreover, ISL suppressed oxidative stress by activating the Nrf2/HO-1 (heme oxygenase-1) pathway and increasing antioxidative enzyme (SOD and GSH) levels. These data suggested that ISL may be a promising therapeutic chemical for AP in the future (Liu et al. 2018).