2016) and neuroprotective (Wang et al. 2018) properties. In cerulein-induced AP mice, calycosin treatment protected pancreatic tissue from oxidative damage by reducing MPO activity and increasing SOD activity. In addition, calycosin exerted an anti-inflammatory effect against pancreatic damage by mitigating the levels of the inflammatory cytokines TNF-α, IL-1β and IL-6. Calycosin decreased the expression level of NF-κB p65 and inhibited the phosphorylation levels of IκBα and p38 MAPK (Ma et al. 2018). This evidence concerns the gene TNF and alkaline phosphatase measurement.