2019). Herein, the inhibition of trypsinogen activation would be beneficial for the treatment of AP. Recent evidence demonstrated that mogroside IIE ameliorated AP through inhibition of the IL-9/IL-9 receptor pathway, which increased cytosolic calcium and the activity of cathepsin B and trypsin, and induced impaired autophagy (Xiao et al. 2020). This evidence concerns the gene CTSB and alkaline phosphatase measurement.