In agreement with our proposed model, PHF8 levels positively correlate with the expression of its transcriptional targets (e.g., SMAD3 and SMAD4; Fig. 6E) across multiple transcriptomic datasets [TCGA Skin Cutaneous Melanoma (SKCM) (13), Kabbarah et al. (7), and Xu et al. (10)] in which PHF8 was found up-regulated in metastasis versus primary melanoma (fig. This evidence concerns the gene SMAD4 and melanoma.