PHF8 and neoplasm: Although PHF8 knockout did not affect primary tumor growth (Fig. 4B) or tumor mass at termination of the experiment (40 days) (Fig. 4C), it led to a significant decrease in lung metastasis burden measured by ex vivo bioluminescence (Fig. 4D), which corresponded to a reduced number of metastatic foci (Fig. 4, E to G).