Close examination of hematoxylin and eosin–stained liver sections and histopathological scoring of the tumor content showed markedly smaller tumor islands in the exoASO-STAT6–treated mice and conspicuous immune infiltrate colocalizing with tumor areas (Fig. 5C), with 50% of the animals presenting major pathological responses (tumor area < 10%), including one mouse with complete remission (tumor area ≤ 1%). Here, STAT6 is linked to neoplasm.